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Updated: May 30, 2025

Induction and Analysis of Epithelial to Mesenchymal Transition
Published on: August 27, 2013
Correlation of P53 expression and epithelial-mesenchymal transition in non-small cell lung cancer
1Department of Pathology, Beijing Geriatric Hospital, Beijing, China.
Background:
Investigation of a potential prognostic marker expressed in non-small cell lung cancer (NSCLC) can help patients benefit from new target therapeuticmodalities.
Aims:
To study the expression and correlation of P53 protein and epithelial-mesenchymal transition (EMT) related makers in NSCLC.
Materials And Methods:
32 cases were selected for immunohistochemistry analysis to evaluate the expression of P53 and EMT-related makers.
Results:
The positive expression rate of P53 and the incidence of EMT in NSCLC were closely linked to TNM stages, differentiation degree, and lymph node metastasis ( P < 0.05). A positive association was found between P53 and EMT ( r = 0.380 , P < 0.05).
Conclusions:
There is a positive association between P53 , snail, and EMT. P53 may affect EMT in NSCLC by up-regulating the expression of Snail and further promoting cancer invasion and metastasis.
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