THE ROLE OF PLASMA COPEPTIN LEVEL IN DETERMINING THE SEVERITY AND MORTALITY OF SUBARACHNOID HEMORRHAGE

Area of Science:

• Neurology
• Biomarkers
• Emergency Medicine

Background:

• Subarachnoid hemorrhage (SAH) is a critical neurological condition.
• Accurate diagnosis and prognosis are essential for patient management.
• Plasma copeptin is a potential biomarker for various medical conditions.

Purpose of the Study:

• To evaluate the utility of plasma copeptin levels in diagnosing subarachnoid hemorrhage (SAH).
• To assess the correlation between plasma copeptin levels and SAH severity.
• To determine the role of plasma copeptin in predicting mortality in SAH patients.

Main Methods:

• Adult patients diagnosed with SAH were enrolled.
• Plasma copeptin levels were measured at emergency department admission.
• Neurological status was assessed using Glasgow Coma Scale (GCS), World Federation of Neurological Surgeons (WFNS), and modified Fisher score.

Main Results:

• Plasma copeptin levels were significantly higher in SAH patients compared to healthy controls (p=0.001).
• No significant correlation was found between plasma copeptin levels and GCS, WFNS, or modified Fisher scores.
• Plasma copeptin levels did not differ significantly between patients who survived and those who died in-hospital (p=0.41).

Conclusions:

• Plasma copeptin may serve as a diagnostic marker for subarachnoid hemorrhage.
• Plasma copeptin levels are not reliable indicators of SAH severity or patient mortality.