The Association Between Tuberculosis and Osteoporosis: A Systematic Review and Meta-Analysis

Recent research suggests that tuberculosis (TB) may pose a potential risk factor for osteoporosis, although the available evidence remains limited. This study aimed to comprehensively assess osteoporosis risk in TB patients through systematic review and meta-analysis methodology. Two investigators independently conducted a literature search using the Medical Literature Analysis and Retrieval System Online (MEDLINE) and Excerpta Medica Database (EMBASE) databases up to April 2024. Eligible longitudinal cohort studies had to evaluate the impact of active or a history of TB on the risk of osteoporosis and/or osteoporotic fractures. Point estimates and standard errors from each eligible study were pooled using DerSimonian and Laird's generic inverse variance method. Of 2,062 articles (1,765 from EMBASE and 297 from MEDLINE) reviewed, three retrospective cohort studies, comprising a total of 531,624 participants (174,726 patients with TB and 356,898 participants without TB), met the eligibility criteria and were included in the meta-analysis. The pooled analysis of three studies revealed an increased risk of osteoporosis among TB patients, with a pooled hazard ratio of 1.40 (95% CI, 1.26 - 1.57; I = 54%). The pooled analysis indicated that populations with TB also had a higher risk of osteoporotic fractures than populations without TB, with a pooled hazard ratio of 1.65 (95% CI, 1.26 - 2.15; I = 71%). Our systematic review and meta-analysis demonstrated a significantly increased risk of osteoporosis and osteoporotic fractures in patients with TB.