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Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans
Published on: November 26, 2017
Orsay virus infection rate declines with age in C. elegans
Shivaani Tishadas1,2, Kentaro Noma1
1Nagoya University, Nagoya, Aichi, Japan.
Abstract:
The intracellular pathogen response is regulated by multiple pals genes in C. elegans . How such responses change with age is largely unknown. Thus, we investigated potential age-dependent changes in the immune response to the C. elegans -specific Orsay virus . When animals were exposed to equal viral concentrations, the expression of known immune-response pals genes and viral RNAs was lower in aged populations than in young adults. However, when young and aged populations were infected with equal viral loads, pals gene expression did not change with age. Therefore, aged C. elegans experience a decline in viral infection rate.
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