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Iron metabolism in rheumatic diseases
Aliakbar Givian1,2, Amin Azizan1,3, Ahmadreza Jamshidi1
1Rheumatology Research Center, Tehran University of Medical Science, Tehran, Iran.
Journal of Translational Autoimmunity
|January 27, 2025
Summary
Iron is vital for bodily functions, but its regulation is impaired in rheumatic diseases like rheumatoid arthritis. This review explores how iron metabolism contributes to disease progression.
Area of Science:
- Biochemistry
- Immunology
- Rheumatology
Background:
- Iron is essential for oxygen transport, hematopoiesis, and immune function.
- The human body has evolved sophisticated mechanisms for iron regulation.
- Impaired iron homeostasis is implicated in various physiological processes.
Purpose of the Study:
- To review the role of iron metabolism in rheumatic diseases.
- To elucidate how altered iron homeostasis contributes to disease progression.
Main Methods:
- Literature review focusing on iron metabolism and rheumatic diseases.
- Analysis of the impact of iron dysregulation on disease pathogenesis.
Main Results:
- Rheumatic diseases such as rheumatoid arthritis, SLE, SSc, AS, and gout exhibit impaired iron regulation.
- Altered iron homeostasis promotes disease progression via oxidative stress, fibrosis, and inflammation.
Conclusions:
- Iron metabolism is a critical factor in the pathogenesis of rheumatic diseases.
- Targeting iron dysregulation may offer novel therapeutic strategies for rheumatic conditions.
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