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Updated: May 30, 2025
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Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain
Published on: August 8, 2019
Hippocampal Functional Radiomic Features for Identification of the Cognitively Impaired Patients from
Ziwei Yang1,2, Xiao Liang1,2, Yuqi Ji1,2
1Jiangxi Provincial Key Laboratory for Precision Pathology and Intelligent Diagnosis, Department of Radiology, the First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People's Republic of China.
Functional radiomic features in the hippocampus can identify cognitive impairment in patients with low-back-related leg pain (LBLP). This approach shows high accuracy in distinguishing impaired individuals, aiding diagnosis.
Area of Science:
- Neuroimaging
- Radiomics
- Cognitive Science
Background:
- Low-back-related leg pain (LBLP) can be associated with cognitive impairment.
- Early identification of cognitive decline in LBLP patients is crucial for timely intervention.
Purpose of the Study:
- To determine if functional radiomic features of the bilateral hippocampi can differentiate cognitively impaired patients from those with LBLP.
- To explore the diagnostic potential of hippocampal radiomics in LBLP.
Main Methods:
- Retrospective analysis of 95 LBLP patients (40 cognitively impaired, 45 cognitively preserved).
- Functional MRI data analyzed using Amplitude of Low-Frequency Fluctuations (ALFF), Regional Homogeneity (ReHo), Voxel-Mirrored Homotopic Connectivity (VMHC), and Degree Centrality (DC).
- Extracted 819 radiomic features from bilateral hippocampi, followed by feature selection and machine learning model training.
Main Results:
- A logistic regression model using combined radiomic features achieved superior performance (AUC = 0.970, accuracy = 92.3%) in distinguishing cognitively impaired LBLP patients.
- Radiomic wavelet features correlated significantly with cognitive assessments (MoCA) and anxiety scores in impaired LBLP patients.
Conclusions:
- Functional radiomic features of the hippocampus are valuable biomarkers for diagnosing cognitive impairment in LBLP patients.
- This radiomic approach offers a promising non-invasive method for identifying cognitive decline in this population.
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