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Brain Imaging Investigation of the Impairing Effect of Emotion on Cognition

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Published on: February 1, 2012

Neural Correlates of Irritability and Potential Moderating Effects of Inhibitory Control.

Mariah DeSerisy^1,2, Jacob W Cohen^2,3, Huiyu Yang³

¹Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.

Biological Psychiatry Global Open Science

|January 27, 2025

Summary

Irritability in youth is linked to altered brain connectivity, particularly in young boys. Reduced connectivity between threat, reward, and cognitive control networks may explain difficulties in emotional regulation.

Keywords:

Cognitive control Inhibitory control Irritability Network-based analyses Reward processing Threat processing

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Published on: February 1, 2012

Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention

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Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition

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Published on: February 8, 2018

Area of Science:

Neuroscience
Developmental Psychology
Child Psychiatry

Background:

Irritability affects 20% of youth, leading to pediatric mental health referrals.
Existing research on irritability's neural correlates shows mixed results.
Brain connectivity in cognitive control, reward, and threat circuits is understudied in relation to irritability.

Purpose of the Study:

To investigate associations between irritability and brain connectivity.
To explore the moderating role of inhibitory control on these associations.
To examine connectivity between cognitive control, threat, and reward networks.

Main Methods:

Utilized the Healthy Brain Network dataset (N=4135).
Employed regression models to test hypotheses.
Examined associations between irritability, between-network connectivity, and inhibitory control.

Main Results:

Higher irritability was linked to reduced connectivity between threat, reward, and cognitive control networks in 5- to 9-year-old boys.
Inhibitory control did not moderate the observed associations.
Findings were contrary to the initial hypothesis regarding moderation.

Conclusions:

Reduced between-network connectivity may underlie difficulties in emotional regulation.
This may contribute to increased irritability in some youth.
Further research is needed to understand these complex relationships.