Demographic, anthropometric and intrasubject variations affect platelet-rich plasma formulation

Area of Science:

• Orthopedics and Sports Medicine
• Regenerative Medicine
• Hematology

Background:

• Platelet-rich plasma (PRP) is increasingly used for musculoskeletal pathologies.
• Variability in PRP composition can affect therapeutic outcomes.
• Standardized characterization of PRP is essential for clinical application.

Purpose of the Study:

• To analyze inter- and intra-individual variations in platelet concentration between whole blood and PRP.
• To assess how demographic and anthropometric factors influence these concentrations.
• To evaluate PRP coding systems and intrasubject variability.

Main Methods:

• Retrospective analysis of 686 patients with musculoskeletal pathologies treated with PRP.
• Comparison of platelet counts in blood and PRP.
• Analysis of demographic data (age, sex, BMI) and PRP coding systems.

Main Results:

• PRP showed significantly higher platelet concentrations than blood (378 vs. 222 × 10^3/µL).
• Younger age correlated with higher platelet counts in both blood and PRP.
• Higher platelet ratios were observed in males and individuals with higher BMI; intrasubject variability was greater in PRP than in blood.

Conclusions:

• Age, gender, BMI, and intrasubject variations significantly impact PRP formulation.
• These variables are crucial for developing predictable, personalized, and effective PRP therapeutic strategies.