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Related Experiment Video

Updated: Jun 18, 2026

Microfabricated Post-Array-Detectors mPADs: an Approach to Isolate Mechanical Forces
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Pillar arrays as tunable interfacial barriers for microphysiological systems.

Ishan Goswami, Yongdeok Kim, Gabriel Neiman

    Biorxiv : the Preprint Server for Biology
    |January 27, 2025
    PubMed
    Summary

    Researchers developed a new circular pillar array for microphysiological systems (MPS). This tunable barrier precisely controls diffusion and enables better drug screening and disease modeling in engineered tissues.

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    Area of Science:

    • Biomedical Engineering
    • Microfluidics
    • Tissue Engineering

    Background:

    • Traditional microphysiological system (MPS) barriers like membranes have limitations in pore size control, fabrication complexity, and scalability.
    • Existing barrier designs lack tunability for precise control over hydraulic resistance and diffusion.

    Purpose of the Study:

    • To introduce a novel circular pillar array as a tunable interfacial barrier for microfluidic MPS.
    • To overcome the limitations of traditional barriers by offering precise control over pore size, porosity, and hydraulic resistance.
    • To demonstrate the utility of this barrier for engineering physiologically relevant microtissues and disease models.

    Main Methods:

    • Design and fabrication of a circular pillar array with adjustable pillar dimensions.
    • Characterization of barrier properties including pore size, porosity, and hydraulic resistance.
    • Engineering of cardiac microtissues and a heterotypic model with vasculature using the pillar array barrier.

    Main Results:

    • The pillar array provides precise control over barrier properties through simple modifications of pillar dimensions.
    • Demonstrated successful engineering of cardiac microtissues and vascularized heterotypic models within the MPS device.
    • The tunable barrier effectively mimics in vivo diffusion and facilitates cell aggregation for tissue formation.

    Conclusions:

    • The novel circular pillar array offers a scalable and tunable solution for interfacial barriers in MPS.
    • This technology enables the creation of more physiologically relevant models for drug screening, permeability studies, and disease modeling.
    • The ability to compare drug permeability and cell migration in tissues with and without vasculature presents significant potential for preclinical research.