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The diffusible signaling factor family in microbial signaling: a current perspective
G K Wijesinghe1, A H Nobbs1, H M H N Bandara1
1Oral Microbiology, Bristol Dental School, University of Bristol, United Kingdom.
Critical Reviews in Microbiology
|January 27, 2025
Summary
Diffusible signaling factor family (DSFF) molecules, initially found in Gram-negative bacteria, are now recognized across diverse microorganisms. These signaling molecules regulate crucial bacterial behaviors and interactions, offering potential for new antimicrobial therapies.
Area of Science:
- Microbiology
- Molecular Biology
- Biochemistry
Background:
- The diffusible signaling factor family (DSFF) comprises cis-2-unsaturated fatty acids involved in microbial communication.
- DSFFs were initially thought to be exclusive to Gram-negative bacteria but are now found in a wider range of microorganisms.
- Understanding DSFFs is crucial due to their role in microbial ecosystems and potential therapeutic applications.
Purpose of the Study:
- To review the chemical properties, synthesis, detection, and biological functions of DSFFs.
- To highlight the expanding knowledge of DSFFs beyond Gram-negative bacteria.
- To emphasize the therapeutic potential of DSFFs in combating antimicrobial resistance.
Main Methods:
- Literature review of seminal and recent publications on DSFFs.
- Analysis of chemical structures and biological roles of various DSFF molecules (e.g., BDSF, DSF, SDSF).
- Discussion of DSFFs' impact on microbial virulence, adhesion, biofilm formation, motility, and antimicrobial tolerance.
Main Results:
- DSFFs are present in diverse microorganisms, challenging earlier assumptions.
- DSFFs modulate key bacterial processes including virulence, biofilm dynamics, and motility.
- Interactions between DSFFs and other organisms like fungi, plants, and animals have been observed.
Conclusions:
- DSFFs represent a complex signaling system with broad implications in microbial communities.
- Further research into the full spectrum of DSFF members and their functions is warranted.
- DSFFs hold significant promise for developing novel therapeutic strategies against antimicrobial resistance.
Keywords:
Diffusible signaling factorantimicrobial resistancebiofilmsmicrobial interactionsquorum sensingMore Related Videos
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