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Related Experiment Video

Updated: May 30, 2025

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

Acid-Triggered Dual-Functional Hydrogel Platform for Enhanced Bone Regeneration.

Yao Xiao¹, Jinjin Ma², Xiaonan Yuan²

¹The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang, 832000, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)

|January 27, 2025

Summary

This study introduces a smart hydrogel that releases growth factors in response to bone injury's acidic environment, promoting endogenous stem cell recruitment for enhanced bone repair.

Keywords:

Arg‐CDs metabolism acidic microenvironment endogenous stem cells recruitment osteogenesis and angiogenesis coupling

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Last Updated: May 30, 2025

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

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Published on: July 14, 2023

Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry

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Published on: March 29, 2018

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

Area of Science:

Biomaterials Science
Regenerative Medicine
Tissue Engineering

Background:

Stem cell implantation for bone repair carries risks like pathogen transmission.
Recruiting endogenous stem cells is crucial for in situ bone regeneration.
Bone injury creates an acidic microenvironment.

Purpose of the Study:

To develop a dual-intelligent-switch composite hydrogel for bone regeneration.
To leverage the acidic microenvironment of bone injury for controlled drug release.
To promote coupled osteogenesis and angiogenesis for enhanced bone healing.

Main Methods:

Incorporated stromal cell-derived factor-1α (SDF-1α), arginine carbon dots (Arg-CDs), and calcium ions (Ca2+) into an oxidized hyaluronic acid/gelatin methacryloyl (HG) hydrogel.
Engineered a dual-control intelligent switch function triggered by the acidic microenvironment.
Investigated the hydrogel's ability to release SDF-1α and promote nitric oxide (NO) production.

Main Results:

The HG-AA1:1-SDF-1α hydrogel exhibited a dual-intelligent-switch function.
Acidic conditions (pH 5.5) significantly increased SDF-1α release (≈2.5 times higher than pH 7.4).
Recruited mesenchymal stem cells (MSCs) activated NO production, promoting angiogenesis via the NO/cGMP pathway.

Conclusions:

The engineered HG-AA1:1-SDF-1α composite hydrogel effectively recruits endogenous stem cells and promotes angiogenesis.
This approach offers a promising strategy for coupled osteogenesis and angiogenesis in bone regeneration.
The dual-intelligent-switch hydrogel provides a safer and more effective alternative to stem cell implantation for bone repair.