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Related Experiment Video

Updated: Jun 5, 2026

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs
12:44

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

Published on: January 27, 2023

Lesion Site-Targeted Microspheres Modulate Nav1.7-Related Signaling for Osteoarthritis Treatment.

Cheng Chen1,2,3, Jiaying Li2, Jinjin Ma2

  • 1Department of Orthopedic Surgery, The Affiliated Yixing Hospital of Jiangsu University, Wuxi, Jiangsu, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|June 4, 2026
PubMed
Summary

Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

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The effect of extracorporeal shock wave on joint capsule fibrosis based on A<sub>2</sub>AR-Nrf2/HO-1 pathway in a rat extending knee immobilization model.

Journal of orthopaedic surgery and research·2023

This study introduces CBZ/WCOM, a novel drug delivery system for osteoarthritis (OA) that targets cartilage and reduces inflammation and pain by modulating sodium channel activity. This minimally invasive therapy shows promise for local OA treatment.

Area of Science:

  • Biomedical Engineering
  • Pharmacology
  • Orthopedics

Background:

  • Osteoarthritis (OA) involves cartilage degeneration, inflammation, and pain, with Nav1.7 sodium channels implicated in chondrocyte function.
  • Targeted drug delivery systems are needed to improve therapeutic efficacy and minimize side effects in OA treatment.

Purpose of the Study:

  • To develop and evaluate an acid-responsive, cartilage-targeted composite microsphere system (CBZ/WCOM) for sustained intra-articular delivery of carbamazepine (CBZ).
  • To investigate the therapeutic effects of CBZ/WCOM on chondrocytes and in a mouse model of OA.

Main Methods:

  • Developed WYRGRL peptide-modified chondroitin sulfate/oxidized hyaluronan composite microspheres loaded with carbamazepine (CBZ/WCOM).
  • Assessed CBZ/WCOM effects on IL-1β-challenged chondrocytes, measuring inflammatory/catabolic gene expression and ion channel activity.
Keywords:
Nav1.7acid‐responsive deliverycarbamazepineosteoarthritistype II collagen‐targeting peptide

Related Experiment Videos

Last Updated: Jun 5, 2026

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs
12:44

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

Published on: January 27, 2023

  • Evaluated CBZ/WCOM in a mouse destabilization of the medial meniscus (DMM) model, assessing pain, joint structure, and bone alterations.

    • Main Results:

    • CBZ/WCOM attenuated inflammatory and catabolic responses in chondrocytes, partially restoring anabolic markers.
    • CBZ/WCOM modulated Nav1.7-related sodium channel signaling and ion dynamics in chondrocytes.
    • In DMM mice, intra-articular CBZ/WCOM reduced pain, decreased osteophyte formation, preserved joint space, and improved cartilage and bone phenotypes.

    Conclusions:

    • CBZ/WCOM demonstrates potential as a minimally invasive strategy for local OA therapy by targeting lesions and providing sustained drug release.
    • The system leverages cartilage-specific targeting and pH-triggered release for enhanced therapeutic outcomes in osteoarthritis.