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Technical advances in laboratory diagnosis of bloodstream infection

Hainan Wen¹, Liu Qian², Xinghui Gao²

¹Department of Clinical Laboratory, Hebei Key Laboratory of Panvascular Diseases, The Affiliated Hospital of Chengde Medical University, Chengde, Hebei, People's Republic of China.

Expert Review of Molecular Diagnostics

|January 27, 2025

Abstract

Introduction:

Rapid and accurate laboratory diagnosis is essential for the effective treatment of bloodstream infection (BSI).

Areas Covered:

This review aims to address novel and traditional approaches that exhibit different performance characteristics in the diagnosis of BSI. In particular, the authors will discuss the pros and cons of the blood culture-based phenotypic methods, nucleic acid-targeted molecular methods, and host response-targeted biomarker detection in the diagnosis of BSI.

Expert Opinion:

This manuscript summarizes etiologic and host-based techniques in the diagnosis of BSI. Both methods are not mutually exclusive but should be selected based on clinical needs and laboratory conditions to help diagnose BSI more quickly and accurately.

Keywords:

Bloodstream infection antimicrobial susceptibility blood culture host biomarkers laboratory diagnosis molecular methods sepsis

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