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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

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Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy.

Xiuna Jia¹, Erkang Wang¹, Jin Wang^2,3

¹State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China.

Chemical Reviews

|January 27, 2025

Summary

Nanozymes offer promising cancer therapy by converting tumor substances into toxic reactive oxygen species (ROS). Advanced cascade catalytic systems enhance ROS production for effective cancer treatment with fewer side effects.

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Area of Science:

Biomedical Engineering
Nanotechnology
Cancer Therapy

Background:

Nanozymes catalyze tumor substances into reactive oxygen species (ROS) for cancer therapy.
Tumor microenvironment (TME) complexity impacts nanozyme efficiency and ROS generation.
Rational design and activity regulation are crucial for effective nanozyme-based cancer treatment.

Purpose of the Study:

To provide a comprehensive overview of nanozymes in cancer therapy.
To discuss nanozyme activity regulation and rational design strategies.
To summarize nanozyme-based cascade catalytic systems for cancer treatment.

Main Methods:

Review of nanozyme classification and fundamentals.
Detailed discussion on nanozyme activity regulation and design.
Summarization of cascade catalytic systems and their mechanisms.

Main Results:

Nanozymes effectively induce oxidative stress and cancer cell death.
Cascade catalytic systems enhance therapeutic substance production in tumors.
Significant progress has been made in developing efficient nanozyme-based cancer therapies.

Conclusions:

Nanozyme-based cascade catalytic systems show great potential for effective and stable cancer therapy.
Understanding TME factors and optimizing nanozyme design are key to improving ROS generation.
Further research into challenges and prospects will advance biomedical applications.