Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microscale organization and separability of upper extremity representations in the human motor homunculus.

Research square·2026
Same author

Radiofrequency thermoablation of the infraorbital nerve for posttraumatic trigeminal neuropathic pain: illustrative case.

Journal of neurosurgery. Case lessons·2026
Same author

High-resolution cortical mapping within and across the central sulcus using 1024-electrode micro-electrocorticography arrays: illustrative case.

Journal of neurosurgery. Case lessons·2026
Same author

Minimally invasive implantation of scalable high-density cortical microelectrode arrays for multimodal neural decoding and stimulation.

Nature biomedical engineering·2025
Same author

Transorbital Endoscopic Approach for Resection of an Intraorbital Lesion: 2-Dimensional Operative Video.

Operative neurosurgery (Hagerstown, Md.)·2025
Same author

Utilizing an Embedded Critical Ethnography Experience to Help Residents Understand Locally Relevant Social Determinants of Health.

Journal of graduate medical education·2024
Same journal

Spatiotemporally distinctive astrocytic and neuronal responses to repetitive intracortical microstimulation.

Journal of neural engineering·2026
Same journal

A neural mass modelling framework for evaluating EEG source localisation of seizure activity.

Journal of neural engineering·2026
Same journal

Functional and effective connectivity methods from SEEG for characterizing epileptogenic networks in refractory epilepsy: a comprehensive review and future directions.

Journal of neural engineering·2026
Same journal

Online decoding of rat self-paced locomotion speed from EEG using recurrent neural networks.

Journal of neural engineering·2026
Same journal

The seizure embedding map: A spatio-temporal transformer for comparing patients by ictal intracranial EEG features at scale.

Journal of neural engineering·2026
Same journal

Decoding imagined Chinese speech: A capsule neural network based on bidirectional knowledge transfer for hierarchical multi-label classification.

Journal of neural engineering·2026
See all related articles

Related Experiment Video

Updated: May 30, 2025

Surgical Training for the Implantation of Neocortical Microelectrode Arrays Using a Formaldehyde-fixed Human Cadaver Model
08:11

Surgical Training for the Implantation of Neocortical Microelectrode Arrays Using a Formaldehyde-fixed Human Cadaver Model

Published on: November 19, 2017

11.3K

First-in-human experience performing high-resolution cortical mapping using a novel microelectrode array containing

Peter Konrad1, Kate R Gelman1, Jesse Lawrence2

  • 1Department of Neurosurgery, West Virginia University, Morgantown, WV, United States of America.

Journal of Neural Engineering
|January 27, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces micro-electrocorticography, a new brain mapping tool, showing it can precisely locate brain functions during surgery. This technology offers higher resolution for mapping eloquent brain regions in patients with brain tumors.

Keywords:
ECoGbrain–computer interfacescentral sulcus localizationfunctional mappinglanguage mappingmicro-ECoG

More Related Videos

Brain Mapping Using a Graphene Electrode Array
10:32

Brain Mapping Using a Graphene Electrode Array

Published on: October 20, 2023

1.7K
Recording Human Electrocorticographic ECoG Signals for Neuroscientific Research and Real-time Functional Cortical Mapping
13:32

Recording Human Electrocorticographic ECoG Signals for Neuroscientific Research and Real-time Functional Cortical Mapping

Published on: June 26, 2012

25.7K

Related Experiment Videos

Last Updated: May 30, 2025

Surgical Training for the Implantation of Neocortical Microelectrode Arrays Using a Formaldehyde-fixed Human Cadaver Model
08:11

Surgical Training for the Implantation of Neocortical Microelectrode Arrays Using a Formaldehyde-fixed Human Cadaver Model

Published on: November 19, 2017

11.3K
Brain Mapping Using a Graphene Electrode Array
10:32

Brain Mapping Using a Graphene Electrode Array

Published on: October 20, 2023

1.7K
Recording Human Electrocorticographic ECoG Signals for Neuroscientific Research and Real-time Functional Cortical Mapping
13:32

Recording Human Electrocorticographic ECoG Signals for Neuroscientific Research and Real-time Functional Cortical Mapping

Published on: June 26, 2012

25.7K

Area of Science:

  • Neuroscience
  • Medical Technology
  • Electrophysiology

Background:

  • Accurate brain function localization is crucial in clinical neuroscience, but anatomical variations and disorders complicate traditional methods.
  • Existing functional neuroanatomy relies on structural landmarks, which may not align with actual functional regions, especially in patients with altered brain tissue.
  • Precise correlation of neural activity with cognition and behavior is needed for individualized diagnosis and treatment.

Purpose of the Study:

  • To evaluate the feasibility and clinical utility of novel 1024-channel micro-electrocorticography (micro-ECoG) arrays for intraoperative functional brain mapping.
  • To assess the performance of micro-ECoG in providing high-resolution spatial and temporal mapping of neural activity during neurosurgical procedures.
  • To explore the application of micro-ECoG in mapping both motor and language functions in patients undergoing brain tumor resection.

Main Methods:

  • Conducted a first-in-human study involving eight patients with brain tumors requiring resection of eloquent brain regions.
  • Utilized novel thin-film arrays with 1024 surface microelectrodes for concurrent micro-ECoG mapping during standard electrophysiologic procedures.
  • Performed motor mapping using somatosensory evoked potentials (SSEPs) and awake language mapping, comparing results with conventional techniques.

Main Results:

  • Micro-ECoG successfully mapped functional regions with higher spatial resolution (0.4 mm) compared to conventional methods, identifying SSEP phase reversal as a contour.
  • In Broca's area, micro-ECoG revealed high-amplitude beta-band activity preceding speech articulation, correlating with language planning.
  • Demonstrated the ability to capture detailed neural activity patterns related to specific cognitive and motor tasks intraoperatively.

Conclusions:

  • Micro-electrocorticography is a feasible technology for intraoperative brain mapping.
  • The high-resolution mapping capabilities of micro-ECoG offer potential clinical utility for neurosurgical planning and execution.
  • This technology enhances the systematic cortical mapping of functional brain regions, improving precision in patient care.