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Updated: May 30, 2025

The Use of Reverse Phase Protein Arrays RPPA to Explore Protein Expression Variation within Individual Renal Cell Cancers
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[Molecularly defined renal cell carcinomas].

C Stöhr1,2,3, A Fiegl1,2,3, C Bercebal1,2,3

  • 1Institut für Pathologie, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Krankenhausstraße 8-10, 91054, Erlangen, Deutschland.

Pathologie (Heidelberg, Germany)
|January 27, 2025
PubMed
Summary
This summary is machine-generated.

The 2022 WHO classification introduces molecularly defined tumors, including specific types of renal cell carcinoma (RCC) based on genetic alterations. This advances tumor biology understanding and diagnostic accuracy.

Keywords:
Basic helix-loop-helix leucine zipper transcription factorsImmunohistochemistryMale genital neoplasmsReceptor protein-tyrosine kinasesWorld Health Organization

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Area of Science:

  • Oncology
  • Genetics
  • Pathology

Context:

  • The World Health Organization (WHO) released its 2022 classification of urinary and male genital tumors, incorporating recent scientific advancements.
  • This revision emphasizes molecular characteristics in tumor classification.

Purpose:

  • To summarize the updated recommendations for classifying molecularly defined tumors in the 2022 WHO classification.
  • To highlight the significance of molecular alterations in tumor biology and treatment.

Summary:

  • The 2022 WHO classification introduces a new category for molecularly defined tumors.
  • This includes TFE3-rearranged Renal Cell Carcinoma (RCC), TFEB-altered RCC, ELOC-mutated RCC, FH-deficient RCC, SDH-deficient RCC, ALK-rearranged RCC, and SMARCB1-deficient RCC.
  • These classifications are based on specific genetic alterations impacting tumor biology.

Impact:

  • Facilitates the diagnosis of tumors with potentially equivocal morphologies.
  • Reflects the growing importance of molecular profiling in guiding therapeutic strategies.
  • Provides a framework for understanding tumor heterogeneity and developing targeted treatments.