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Related Experiment Video

Updated: May 30, 2025

Invasive Hemodynamic Assessment for the Right Ventricular System and Hypoxia-Induced Pulmonary Arterial Hypertension in Mice
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hUC-MSCs Prevent Acute High-Altitude Injury through Apoe/Pdgf-b/p-Erk1/2 Axis in Mice.

Siyu Yan1, Youkun Bi1,2, Qun Liu2

  • 1Chinese Academy of Medical Sciences & Peking Union Medical College Fuwai Hospital, Beijing, China.

Stem Cell Reviews and Reports
|January 27, 2025
PubMed
Summary

Human umbilical cord mesenchymal stem cells (hUC-MSCs) prevent high-altitude sickness by protecting organs from hypobaric hypoxia. This study reveals hUC-MSCs protect against lung, heart, and brain injury via the Apoe/Pdgf-b/p-Erk1/2 pathway.

Keywords:
Acute mountain sicknessApoeHUC-MSCsHypobaric hypoxia

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Area of Science:

  • Stem cell therapy
  • High-altitude physiology
  • Pathology

Background:

  • Hypobaric hypoxic environments pose significant health risks.
  • Acute pathological injury can result from high-altitude exposure.
  • Understanding preventive mechanisms is crucial for mitigating altitude sickness.

Purpose of the Study:

  • To investigate the preventive effects of human umbilical cord mesenchymal stem cells (hUC-MSCs) on acute pathological injury.
  • To elucidate the underlying mechanisms of hUC-MSCs in mitigating high-altitude-induced damage.
  • To explore hUC-MSCs as a potential therapeutic strategy for hypobaric hypoxia.

Main Methods:

  • Mice were pretreated with hUC-MSCs and exposed to hypobaric hypoxia.
  • Pathological injury in the lung, heart, and brain was assessed using biochemical, histopathological, qPCR, and Western blot analyses.
  • Transcriptome sequencing identified potential therapeutic targets and signaling pathways, including the Apoe/Pdgf-b/p-Erk1/2 axis, which was further validated.

Main Results:

  • hUC-MSCs administration alleviated gastrointestinal symptoms and inflammation in the lung and heart.
  • Treatment improved blood oxygen saturation, antioxidant levels (SOD), and reduced oxidative stress markers (MDA).
  • hUC-MSCs protected lung and heart tissues, improved brain tissue integrity, and reduced edema, mediated by the Apoe/Pdgf-b/p-Erk1/2 pathway.

Conclusions:

  • hUC-MSCs demonstrate significant preventive effects against acute pathological injury induced by hypobaric hypoxia.
  • The study identified the Apoe/Pdgf-b/p-Erk1/2 signaling axis as a key mechanism for hUC-MSCs' protective action.
  • hUC-MSCs represent a promising therapeutic approach for managing high-altitude-related pathologies.