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Updated: May 30, 2025

Oral Health Assessment by Lay Personnel for Older Adults
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Oral microbiota in aging and diseases.

Ya Ren1, Mingxu Chen1,2, Ziyang Wang1

  • 1Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Center for Quantitative Biology (CQB), Peking University, Beijing 100871, China.

Life Medicine
|January 28, 2025
PubMed
Summary

The human oral microbiome plays a crucial role in health and disease. Research suggests that altering oral microbial composition may offer new strategies for preventing diseases and intervening in the aging process.

Keywords:
agingdiseaseoral microbiome

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Area of Science:

  • Microbiology
  • Human Microbiome Research
  • Aging Biology

Background:

  • The human body hosts numerous microbial communities, with the oral cavity being a significant habitat and the first line of defense against pathogens.
  • Oral microbial dysbiosis is linked to both oral and systemic diseases, including aging-related conditions.
  • Oral microorganisms can impact systemic health through ingestion or translocation into the bloodstream.

Purpose of the Study:

  • To explore the connection between oral microbiota and systemic health, particularly in the context of aging.
  • To investigate the role of oral microbial dysbiosis in inflammatory aging (inflammaging).
  • To propose the oral microbiome as a target for disease prevention and aging intervention.

Main Methods:

  • Review of existing literature on oral microbiota composition and its relation to health and disease.
  • Analysis of pathways through which oral microorganisms influence systemic inflammation and aging.
  • Exploration of the concept of inflammaging and its link to oral pathogenic microbes.

Main Results:

  • Oral microbial composition changes throughout different life stages.
  • Oral pathogenic microbes are implicated in contributing to inflammatory aging via systemic inflammation.
  • Oral microbial dysbiosis is associated with increased risk of systemic diseases and accelerated aging.

Conclusions:

  • The oral microbiome is a critical factor in maintaining overall health and influencing the aging process.
  • Modulating the oral microbiome presents a potential therapeutic strategy for managing age-related diseases and interventions.
  • Further research into aging oral microbiota is essential for developing targeted health strategies.