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Microfluidics engineering towards personalized oncology-a review.

Sushmita Mishra¹, Murali Kumarasamy¹

¹Department of Biotechnology, National Institute of Pharmaceutical Education and Research, Hajipur (NIPERHajipur) Export Promotion Industrial Park (EPIP), Industrial Area, Vaishali, 844102 Bihar India.

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Summary

Microfluidic technologies enable the isolation of cancer biomarkers from blood, advancing precision oncology. These methods offer minimally invasive tumor assessment and rapid prototyping for future cancer research.

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Area of Science:

Biomedical Engineering
Oncology
Microfluidics

Background:

Precision oncology medicine (POM) relies on identifying and monitoring cancer metastasis and heterogeneity.
The relocation of cancer cells, a key aspect of metastasis, remains a critical area of study.
Microfluidic technologies have emerged as powerful tools for biomarker isolation.

Purpose of the Study:

To review the application of microfluidic technologies in precision oncology.
To discuss the integration of active and passive microfluidic systems.
To explore future prospects of low-cost, rapid-prototyping microfluidics in cancer research.

Main Methods:

Isolation of circulating tumor cells (CTCs) from blood samples.
Detection of tumor-derived vesicles (exosomes) using microfluidic devices.

Keywords:

Circulating DNA Circulating tumor cells Exosomes Microfluidics technologies Precision oncology

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Analysis of cell-free nucleic acids and proteins via microfluidic platforms.

Distinguishing between active (external fields) and passive (fluid forces) microfluidic approaches.

Main Results:

Microfluidics facilitates minimally invasive and quantitative tumor assessment.
Development of methods for isolating diverse cancer biomarkers, including CTCs and exosomes.
Potential for integrating active and passive microfluidic strategies for enhanced detection.

Conclusions:

Microfluidics is revolutionizing precision oncology by enabling comprehensive tumor analysis.
Future advancements in low-cost, rapid-prototyping microfluidics promise wider accessibility and application in cancer research.
The integration of microfluidic technologies is crucial for understanding and combating cancer metastasis.