Bioactive surface-functionalized MXenes for biomedicine

MXenes, with their good biocompatibility, excellent photovoltaic properties, excellent physicochemical properties, and desirable bioactivity, have broad application prospects in the field of tissue regeneration. MXenes have been used in a wide range of applications including biosensing, bioimaging, tumour/infection therapy, bone regeneration and wound repair. By applying bioactive materials to modify the surface of MXenes, a series of multifunctional MXene-based nanomaterials can be designed for different biomedical applications to achieve better therapeutic effects or more desirable biological functions. This paper reviews the existing studies on MXene-based bioactivities, surface modification strategies and biomedical applications. Finally, the challenges, trends and prospects of MXene nanomaterials are discussed. We expect that more and more well-designed MXene-based biomaterials will have a wider range of biomedical applications, thus providing favourable information for the clinical translation of nanomedicine.