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Effect of acetazolamide (Diamox) on tear secretion
Documenta Ophthalmologica. Advances in Ophthalmology
|January 31, 1985
Summary
Acetazolamide (Diamox) did not affect tear production in rats. However, lacrimal peroxidase secretion significantly decreased during treatment but returned to normal after the drug was stopped.
Area of Science:
- Ophthalmology
- Pharmacology
- Biochemistry
Background:
- Acetazolamide (Diamox) is a carbonic anhydrase inhibitor used clinically for various conditions.
- Its effects on ocular physiology, particularly lacrimation, require further elucidation.
- Understanding drug-induced changes in tear film components is crucial for patient care.
Purpose of the Study:
- To investigate the side effects of acetazolamide on rat lacrimation.
- To quantify the impact of acetazolamide on tear production and lacrimal peroxidase secretion.
Main Methods:
- The study utilized the cotton-thread tear test in rats to measure tear production.
- Rats received a daily oral dose of 1 mg acetazolamide for five days.
- Lacrimal peroxidase secretion levels were assessed before, during, and after drug administration.
Main Results:
- Daily oral administration of acetazolamide did not significantly alter tear production.
- A notable decrease of 60% in baseline lacrimal peroxidase secretion was observed during acetazolamide treatment.
- Following drug withdrawal, lacrimal peroxidase secretion returned to pre-treatment baseline levels.
Conclusions:
- Acetazolamide treatment in rats did not impair overall tear production.
- The drug significantly reduced lacrimal peroxidase secretion, suggesting a specific biochemical side effect.
- The observed effect on lacrimal peroxidase is reversible upon cessation of acetazolamide therapy.