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Design, Structure Optimization, and Preclinical Characterization of JAB-21822, a Covalent Inhibitor of KRASG12C

Amin Li1, Sujing Li1, Peng Wang2

  • 1Medicinal Chemistry Department, Jacobio Pharmaceuticals Group Co., Ltd., Beijing 100176, P. R. China.

Journal of Medicinal Chemistry
|January 28, 2025
PubMed
Summary

A new drug, JAB-21822, effectively targets the KRAS G12C mutation common in cancers like lung cancer. This covalent inhibitor shows high potency and favorable pharmacokinetics, advancing to clinical trials.

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