Selenium-Enriched Lactiplantibacillus plantarum ZZU 8-12 Regulates Intestinal Microbiota and Inhibits Acute Liver...

Area of Science:

• Microbiology
• Gastroenterology
• Toxicology

Background:

• Certain Lactiplantibacillus strains show promise in preventing acute liver injury (ALI).
• Developing novel strategies for ALI prevention is crucial due to its significant health implications.

Purpose of the Study:

• To develop a prevention strategy for ALI using a selenium-enriched Lactiplantibacillus strain.
• To investigate the efficacy of selenium-enriched L. plantarum ZZU 8-12 in preventing carbon tetrachloride (CCL4)-induced ALI in a mouse model.

Main Methods:

• Isolation and screening of L. plantarum ZZU 8-12 for gut adaptation, antibacterial properties, and anti-inflammatory effects.
• Production of selenium-enriched L. plantarum ZZU 8-12 using the strain as a nano selenium particle producer.
• Assessment of the impact of selenium-enriched L. plantarum ZZU 8-12 on fecal microbiota composition and short-chain fatty acid (SCFA)-producing bacteria.
• Evaluation of ALI inhibition in mice induced by CCL4 injection after oral administration of selenium-enriched L. plantarum ZZU 8-12.

Main Results:

• Selenium-enriched L. plantarum ZZU 8-12 successfully modulated the gut microbiota, upregulating SCFA-producing genera like Lactiplantibacillus and Butyricicoccus.
• Oral intake of selenium-enriched L. plantarum ZZU 8-12 significantly inhibited CCL4-induced acute liver injury in mice.
• The probiotic intervention demonstrated a protective effect on liver function.

Conclusions:

• Selenium-enriched L. plantarum ZZU 8-12 holds potential as a functional food ingredient for ALI prevention.
• This strategy leverages the synergistic effects of probiotics and selenium for enhanced hepatoprotection.
• Modulation of gut microbiota and SCFA production are key mechanisms underlying the observed ALI protection.