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Related Concept Videos

pH01:24

pH

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The potential of hydrogen (pH) is a measure of the acidity or basicity of a water-based solution determined by the concentration of hydronium ions (H3O+). In one liter of pure water at neutral pH, there are 1×10−7 moles of hydronium ions. However, the extensive range of hydronium ion concentrations present in water-based solutions makes measuring pH in moles cumbersome. Therefore, a pH scale was developed to convert moles of hydronium ions into the negative logarithm of the hydronium...
121.5K

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Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing
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pH-responsive hydrogels embedded in hollow-core optical resonators.

Médéric Loyez, Maxwell Adolphson, Jie Liao

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    |January 29, 2025
    PubMed
    Summary
    This summary is machine-generated.

    This study demonstrates a novel method for creating pH-sensitive poly(vinyl alcohol)/poly(acrylic acid) (PVA/PAA) hydrogels within whispering-gallery-mode microbubble resonators (MBRs). These hydrogels show tunable wavelength shifts in response to pH changes, enabling sensitive detection.

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    Area of Science:

    • Optics and Photonics
    • Materials Science
    • Biomedical Engineering

    Background:

    • Whispering-gallery-mode (WGM) microresonators offer high sensitivity for surface (bio)chemical sensing.
    • Existing WGM applications focus on refractive index changes near the resonator surface.
    • Monitoring molecular binding events is a key application in biosensing.

    Purpose of the Study:

    • To investigate the gelling of PVA/PAA hydrogels within WGM microbubble resonators (MBRs).
    • To characterize the pH-dependent swelling behavior of these hydrogels.
    • To explore the potential for tunable pH sensing using MBRs.

    Main Methods:

    • Fabrication of MBRs from silica capillaries.
    • In-situ formation of PVA/PAA hydrogel layers within the MBR cavity via controlled heating.
    • Testing the MBRs under varying pH solutions to observe resonance condition changes.
    • Characterization of hydrogel swelling and WGM wavelength shifts.

    Main Results:

    • Successful gelling and characterization of PVA/PAA hydrogel layers inside MBRs.
    • Observed wavelength shifts in WGM resonance proportional to pH variations.
    • Demonstrated the swelling ability of hydrogels in response to different pH levels.
    • Preliminary data on the kinetics, reversibility, and tunable detection capabilities.

    Conclusions:

    • PVA/PAA hydrogels can be effectively integrated into MBRs for sensing applications.
    • The pH-dependent swelling of hydrogels causes measurable changes in WGM resonance.
    • This system shows promise for tunable and sensitive detection of small pH changes.