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Related Concept Videos

Recombinant DNA01:09

Recombinant DNA

Overview
Viral Recombination00:57

Viral Recombination

Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.

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Updated: Jul 10, 2026

Efficient Recombinant Parvovirus Production with the Help of Adenovirus-derived Systems
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Recombinant VSVs: A Promising Tool for Virotherapy.

K A Vorona1, V D Moroz1, N B Gasanov1

  • 1Sirius University of Science and Technology, Krasnodar Region, Sirius Federal Territory, 354340 Russian Federation.

Acta Naturae
|January 29, 2025
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Vesicular stomatitis virus (VSV) shows promise as an oncolytic virus therapy for cancer. This review explores VSV

Keywords:
biomarker of resistancecancer immunotherapyinterferon-stimulated geneoncolytic virusesvesicular stomatitis virus

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Area of Science:

  • Oncology
  • Virology
  • Biotechnology

Background:

  • Cancer remains a leading global cause of mortality, driving the need for novel therapeutic strategies.
  • Current treatments like surgery, radiotherapy, and chemotherapy have limitations, necessitating innovative approaches.
  • Oncolytic viruses, such as vesicular stomatitis virus (VSV), are emerging as a promising alternative for cancer treatment.

Purpose of the Study:

  • To review the potential of vesicular stomatitis virus (VSV) as an oncolytic agent.
  • To discuss VSV's mechanisms of action, oncogenesis, and tumor cell resistance.
  • To examine the development and clinical application of VSV-based cancer therapies.

Main Methods:

  • Literature review of oncogenesis and antiviral responses.
  • Analysis of VSV properties and recombinant VSV production.
  • Examination of clinical trial data for VSV virotherapy.

Main Results:

  • VSV exhibits oncolytic properties, making it a candidate for cancer therapy.
  • Understanding tumor cell resistance and antiviral responses is crucial for VSV efficacy.
  • Recombinant VSV can be engineered to enhance its therapeutic potential.

Conclusions:

  • VSV-based virotherapy holds significant promise for cancer treatment.
  • Further research and clinical trials are necessary to establish VSV as an approved therapy.
  • VSV offers a novel approach to targeting and eliminating malignant tumors.