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Antigen Presenting Cells

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...

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Related Experiment Video

Updated: May 30, 2025

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

Published on: April 29, 2015

A physics informed neural network approach to quantify antigen presentation activities at single cell level using

Chi Zhang¹, Jia Wang², Pengtao Dang³

¹Indiana University School of Medicine.

Research Square

|January 29, 2025

Summary

This summary is machine-generated.

We developed PSAA, a novel systems biology tool, to quantify major histocompatibility complex (MHC) antigen presentation activity from omics data. This method enhances understanding of immune responses in diseases like cancer and infection.

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Last Updated: May 30, 2025

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

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Published on: April 29, 2015

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Published on: January 7, 2019

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

Area of Science:

Immunology
Systems Biology
Computational Biology

Background:

Major histocompatibility complex (MHC) class I and II antigen presentation are crucial for immune surveillance but challenging to quantify dynamically.
Disruptions in MHC pathways are implicated in cancer, infection, and autoimmunity, hindering therapeutic strategies.

Purpose of the Study:

To introduce PSAA (PINN-empowered Systems Biology Analysis of Antigen Presentation Activity), a computational framework for estimating sample-specific MHC antigen presentation activity.
To enable detailed, stepwise quantification of MHC pathway dynamics using diverse omics data.

Main Methods:

PSAA reconstructs MHC pathways and utilizes pathway flux estimation.
The framework analyzes bulk, single-cell, and spatially resolved transcriptomics or proteomics data.
It predicts gene-specific impacts and downstream immune interactions.

Main Results:

PSAA demonstrated robust prediction accuracy across various omics datasets and experimental validations.
The tool proved effective in diverse disease contexts, including cancer and infection.
It successfully linked antigen presentation activity to immune cell function and clinical outcomes.

Conclusions:

PSAA provides a comprehensive framework for analyzing MHC antigen presentation dynamics using omics data.
The tool aids in elucidating disease mechanisms and identifying potential therapeutic targets.
PSAA facilitates a deeper understanding of immune evasion and therapeutic responses.