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Skin microbiota: pathogenic roles and implications in atopic dermatitis.
Cong Huang1,2, Fan Zhuo1,2, Yang Guo1,2,3
1Department of Dermatology, Skin Research Institute of Peking University Shenzhen Hospital, Peking University Shenzhen Hospital, Shenzhen, China.
Frontiers in Cellular and Infection Microbiology
|January 29, 2025
Summary
Atopic dermatitis (AD) involves skin barrier and immune issues linked to microbial imbalance. Restoring skin microbial balance shows promise for managing AD effectively.
Area of Science:
- Dermatology
- Microbiology
- Immunology
Background:
- Atopic dermatitis (AD) is a chronic inflammatory skin condition.
- Impaired skin barrier function and immune dysregulation are key features of AD.
- Skin microbiota dysbiosis is increasingly recognized in AD pathogenesis.
Purpose of the Study:
- To review changes in skin microbiota associated with AD.
- To outline the role of skin microbiota in AD development.
- To summarize therapeutic strategies for restoring microbial homeostasis in AD.
Main Methods:
- Literature review of studies on skin microbiota in AD.
- Analysis of endogenous and external factors affecting skin microbiota.
- Evaluation of current and emerging therapeutic approaches.
Main Results:
- Significant alterations in skin microbial composition are observed in AD patients.
- Dysbiosis contributes to AD pathogenesis and development.
- Treatments like topical therapies, phototherapy, and biologics modulate skin microbiota.
- Therapeutics targeting microbial homeostasis show potential in early studies.
Conclusions:
- Skin microbiota dysbiosis is integral to atopic dermatitis.
- Understanding microbial alterations is crucial for AD management.
- Restoring skin microbial balance represents a promising therapeutic avenue for AD.
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