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Heteroannulations of cyanoacetamide-based MCR scaffolds utilizing formamide
Marios Zingiridis1, Danae Papachristodoulou1, Despoina Menegaki1
1Department of Chemistry, University of Crete, Voutes, 71003 Heraklion, Greece.
Abstract:
C1 chemistry has a central role in the efficient utilization of single-carbon molecules, contributing significantly to sustainability, innovation and economic growth across various sectors. In this study, we present an efficient and rapid method for synthesizing a variety of heteroannulated pyrimidones using cyanoacetamide-based multicomponent reaction (MCR) chemistry. By utilizing specific MCR-based scaffolds as precursors and employing the abundant and inexpensive formamide as a C1 feedstock under neat conditions, we were able to efficiently access substituted thieno-, quinolino- and indolopyrimidones without the need of column chromatography. Further, a single-crystal X-ray structure was obtained, revealing certain geometrical features.
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