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Updated: May 30, 2025

In Vivo Assay for Detection of Antigen-specific T-cell Cytolytic Function Using a Vaccination Model
Published on: November 28, 2017
Vaccine-Induced Annular Atrophic Lichen Planus
Curtis Perz1, Jay Chittoor2, Liesel Grenier2
1Philadelphia College of Osteopathic Medicine, Philadelphia, PA 19131, USA.
Abstract:
Annular atrophic lichen planus (AALP) is a chronic subtype of lichen planus that classically does not respond to treatment with topical steroids. An inflammatory reaction in the dermal infiltrate may play a role in the development of AALP, but the exact pathogenesis remains unclear. We present the case of a 54-year-old-female with lesions on her trunk and extremities that developed following vaccination. Her failed treatment response warranted further workup for AALP, which was confirmed around 1 year after initiation. Although vaccine-induced lichen planus is not common, it has been reported in various cases. We present a rare case of AALP following vaccination and then provide an in-depth discussion of factors associated with the condition and current treatment response.
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