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CARDIOVASCULAR RISK BEFORE AND AFTER SURGICAL TREATMENT OF SEVERE OBESITY
Lilian Cardia1, Alexandre Viera Gadducci1, Denis Pajecki1
1Universidade de São Paulo, Faculty of Medicine, Department of Gastroenterology - São Paulo (SP), Brazil.
Summary
Bariatric surgery significantly improves cardiovascular risk by reducing insulin resistance and metabolic syndrome, as indicated by changes in the atherogenic index of plasma (AIP). This study assessed these effects in over 600 patients.
Area of Science:
- Cardiology
- Metabolic Health
- Surgical Research
Background:
- Obesity is a major risk factor for cardiovascular mortality and associated comorbidities.
- The atherogenic index of plasma (AIP) serves as a key indicator for insulin resistance.
Purpose of the Study:
- To evaluate cardiovascular risk markers before and after bariatric surgery for obesity.
- To assess the impact of obesity surgery on the atherogenic index of plasma (AIP).
Main Methods:
- Analysis of electronic records for 615 patients who underwent bariatric surgery (2007-2012).
- Calculation of AIP (triglyceride/high-density lipoprotein cholesterol) preoperatively and postoperatively.
- Defined AIP thresholds for insulin resistance: >3.5 mg/dL for men, >2.5 mg/dL for women.
Main Results:
- Preoperative elevated AIP was observed in 117 men and 56.2% of 498 women.
- Postoperative AIP levels showed a trend towards normalization, particularly in women.
- Significant reductions in AIP were noted across different postoperative periods compared to baseline.
Conclusions:
- Bariatric surgery demonstrates a significant positive impact on AIP levels.
- Obesity surgery effectively improves insulin resistance and metabolic syndrome markers.
- Surgical treatment for obesity leads to a reduced risk of cardiovascular diseases.
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