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Cognitive Deficits in Anti-LGI1 Encephalitis Are Linked to Immunotherapy-Resistant White Matter Network Changes

Stephan Krohn1,2, Leonie Müller-Jensen1,3, Joseph Kuchling1,3

  • 1Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt- Universität zu Berlin.

Neurology(R) Neuroimmunology & Neuroinflammation
|January 29, 2025
PubMed
Summary

Anti-leucine-rich, glioma-inactivated 1 encephalitis (LGI1-E) causes cognitive deficits due to white matter (WM) network reorganization. This structural brain change, linked to impaired memory and executive functions, persists despite immunotherapy.

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