Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Preparation and Reactions of Sulfides

Preparation and Reactions of Sulfides

Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.

Preparation and Reactions of Thiols

Preparation and Reactions of Thiols

Thiols are prepared using the hydrosulfide anion as a nucleophile in a nucleophilic substitution reaction with alkyl halides. For instance, bromobutane reacts with sodium hydrosulfide to give butanethiol.

Amines to Sulfonamides: The Hinsberg Test

Amines to Sulfonamides: The Hinsberg Test

The Hinsberg test is a method to identify primary, secondary and tertiary amines, named after its pioneer, Oscar Hinsberg. Here, amines are treated with benzenesulfonyl chloride, also known as the Hinsberg reagent, in the presence of an excess of aqueous base, followed by acidification. Based on the nature of the amines, different changes are observed.
Generally, a primary amine reacts with the Hinsberg reagent to produce an N-substituted benzenesulfonamide. The electron-withdrawing...

Electrophilic Aromatic Substitution: Sulfonation of Benzene

Electrophilic Aromatic Substitution: Sulfonation of Benzene

Sulfonation of benzene is a reaction wherein benzene is treated with fuming sulfuric acid at room temperature to produce benzenesulfonic acid. Fuming sulfuric acid is a mixture of sulfur trioxide and concentrated sulfuric acid.

Structure and Nomenclature of Thiols and Sulfides

Structure and Nomenclature of Thiols and Sulfides

Thiols and sulfides are sulfur analogs of alcohols and ethers, respectively, where the sulfur atom takes the place of the oxygen atom. Thus, thiols are generally represented as RSH, where R is an alkyl substituent and —SH is the functional group. On the other hand, in sulfides, the central sulfur atom is bonded to two hydrocarbon groups on either side. Depending upon the type of group, sulfides can be either symmetrical or asymmetrical. Both thiols and sulfides display a bent geometry,...

Phase II Reactions: Methylation Reactions

Phase II Reactions: Methylation Reactions

Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Safe Approach to meta-Fluorinated Pyridines.

Angewandte Chemie (International ed. in English)·2026

Same author

Isolable Coinage Metal Propylene Complexes and Trigonal Pyramids with Tris(pyridyl)borate Ligands.

Inorganic chemistry·2026

Same author

<i>O</i>-Vinylhydroxylamines for <i>De Novo</i> Pyrrole Synthesis.

Journal of the American Chemical Society·2026

Same author

Replacement of the Piperidine Ring with Aza-Spirocycles Reduces Cardiotoxicity of the Local Anesthetic Drug Bupivacaine.

Journal of medicinal chemistry·2026

Same author

Smallest Bicycles in Medicinal Chemistry: Where Are We Now?

Chemical reviews·2026

Same author

Structural and Biological Insights Into Copper(I) Phosphane Complexes With Boron-Phenylated Poly(3-(CF<sub>3</sub>)Pyrazolyl)- and Poly(6-(CF<sub>3</sub>)-2-pyridyl)-Borates.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026

Search research articles

Related Experiment Video

Updated: May 30, 2025

DNA Methylation: Bisulphite Modification and Analysis

DNA Methylation: Bisulphite Modification and Analysis

Published on: October 21, 2011

A reagent to access methyl sulfones.

Yaroslav Poplavskyi¹, Vasyl Ripenko^1,2, Sergei Bova¹

¹Enamine Ltd, Winston Churchill st. 78, 02094, Kyiv, Ukraine.

Nature Communications

|January 29, 2025

Summary

A new chemical reagent enables the synthesis of novel methyl sulfones and related derivatives. These compounds show promise for applications in medicinal and coordination chemistry.

More Related Videos

Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions

Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions

Published on: July 28, 2022

Improved In-gel Reductive β-Elimination for Comprehensive O-linked and Sulfo-glycomics by Mass Spectrometry

Improved In-gel Reductive β-Elimination for Comprehensive O-linked and Sulfo-glycomics by Mass Spectrometry

Published on: November 20, 2014

Related Experiment Videos

Last Updated: May 30, 2025

DNA Methylation: Bisulphite Modification and Analysis

DNA Methylation: Bisulphite Modification and Analysis

Published on: October 21, 2011

Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions

Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions

Published on: July 28, 2022

Improved In-gel Reductive β-Elimination for Comprehensive O-linked and Sulfo-glycomics by Mass Spectrometry

Improved In-gel Reductive β-Elimination for Comprehensive O-linked and Sulfo-glycomics by Mass Spectrometry

Published on: November 20, 2014

Area of Science:

Organic Chemistry
Medicinal Chemistry
Coordination Chemistry

Background:

Methyl sulfones are important functional groups in various chemical applications.
Accessing novel heteroaromatic sulfones and related derivatives can be challenging.

Purpose of the Study:

To develop a novel chemical reagent for synthesizing methyl sulfones.
To explore the utility of this reagent in creating diverse sulfone derivatives.
To evaluate the potential applications of the synthesized compounds.

Main Methods:

Development of a new chemical reagent for sulfone synthesis.
Reaction of the reagent with various bis-nucleophiles.
Synthesis of alkyl-, CHF2-, CF3-, and bicyclo[1.1.1]pentane-containing sulfone derivatives.

Main Results:

Successful development of a reagent to access methyl sulfones.
Rapid formation of previously unknown heteroaromatic methyl sulfones.
Demonstration of the strategy for diverse derivative synthesis.

Conclusions:

The developed reagent provides efficient access to a range of sulfone compounds.
The synthesized sulfones exhibit potential for medicinal chemistry applications.
The compounds also show promise in coordination chemistry and materials science.