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Thromboplastin activity in amniotic fluid.

I H Omsjø, P Oian, J M Maltau

    Gynecologic and Obstetric Investigation
    |January 1, 1985
    PubMed
    Summary
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    Amniotic fluid consistently shows high thromboplastin activity throughout pregnancy. Endotoxin did not elevate this procoagulant activity in tested samples, regardless of gestational age.

    Area of Science:

    • Obstetrics and Gynecology
    • Hematology
    • Biochemistry

    Background:

    • Thromboplastin plays a crucial role in blood coagulation.
    • Understanding thromboplastin activity in amniotic fluid is vital for obstetric care.
    • Previous research on amniotic fluid thromboplastin is limited.

    Purpose of the Study:

    • To quantify thromboplastin activity in amniotic fluid across different gestational ages.
    • To investigate the effect of endotoxin on amniotic fluid procoagulant activity.

    Main Methods:

    • Amniotic fluid was collected via amniocentesis from 39 pregnant patients (14-40 weeks gestation).
    • Samples were fractionated into supernatant and sediment.
    • Thromboplastin activity was measured using a highly specific and sensitive assay.

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  • Some samples were incubated with endotoxin.

    • Main Results:

    • All tested amniotic fluid samples exhibited very high thromboplastin activity.
    • No significant correlation was observed between thromboplastin activity and gestational age.
    • Incubation with endotoxin did not further increase the procoagulant activity of amniotic fluid.

    Conclusions:

    • Amniotic fluid possesses inherent high thromboplastin activity independent of gestational age.
    • Endotoxin does not appear to be a significant stimulator of procoagulant activity in amniotic fluid.