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Transdermal patch based on pressure-sensitive adhesive: the importance of adhesion for efficient drug delivery
Liuyang Wang1, Junyao Ma1, Jiaxin Li1
1School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning, China.
Expert Opinion on Drug Delivery
|January 30, 2025
Summary
Achieving optimal adhesion in transdermal drug delivery systems is crucial for consistent therapeutic benefits. This review explores adhesion principles, challenges, and strategies for enhancing transdermal patch performance.
Area of Science:
- Pharmaceutical Sciences
- Biomaterials Engineering
- Dermatology
Background:
- Transdermal patches offer sustained drug delivery and stable plasma concentrations.
- Patch efficacy and safety are critically dependent on skin adhesion.
- Adhesion is influenced by a complex interplay of formulation and physiological factors.
Purpose of the Study:
- To review the fundamental principles of adhesion in transdermal patches.
- To identify challenges and influencing factors affecting patch adhesion.
- To discuss strategies and molecular mechanisms for improving transdermal patch adhesion.
Main Methods:
- Comprehensive literature review on transdermal patch adhesion.
- Analysis of pressure-sensitive adhesives (PSAs) and their characteristics.
- Examination of factors impacting adhesion, including skin properties and formulation components.
Main Results:
- Adhesion is a multifaceted issue influenced by PSAs, permeation enhancers, APIs, and excipients.
- Dermatological variations and complex formulation interactions pose significant adhesion challenges.
- New PSA polymers and innovative compositions are key to optimizing adhesion and drug delivery.
Conclusions:
- Consistent transdermal drug delivery requires overcoming complex adhesion challenges.
- Further research into novel PSA polymers and formulation strategies is essential.
- Optimizing the balance between drug release, loading, and adhesion is critical for effective transdermal patches.
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