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Updated: May 30, 2025

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Protocol of the Nutritional, Psychosocial, and Environmental Determinants of Neurodevelopment and Child Mental Health

Eunice Lobo1,2,3, Deepa R1, Siddhartha Mandal4,5

  • 1Indian Institute of Public Health-Bengaluru, Public Health Foundation of India, Bangalore, India.

Wellcome Open Research
|January 30, 2025
PubMed

Insights

Early life adversities impact child development. This study examines combined nutritional, psychosocial, and environmental factors on cognitive and mental health in Indian children, identifying pathways to developmental inequities.

Area of Science:

  • Global Health
  • Developmental Pediatrics
  • Environmental Health

Background:

  • Over 250 million children globally experience suboptimal development due to early life adversities.
  • Previous research focused on independent effects of nutrition, psychosocial factors, and pollutants, neglecting their interactions and cumulative impacts.

Purpose of the Study:

  • Investigate independent, interaction, and cumulative effects of nutritional, psychosocial, and environmental factors on child cognitive development and mental health in India.
  • Identify pathways contributing to child outcome inequities at individual, household, and neighborhood levels.

Main Methods:

  • Mixed-methods prospective cohort study of 1600 caregiver-child dyads (ages 3-10) in urban and rural India.
  • Assessed nutritional status, psychosocial adversities, environmental pollutants, cognitive, and mental health outcomes.
  • Utilized multilevel regression, weighted quantile sum regression, and Bayesian kernel machine regression for exposure effect analysis.

Main Results:

  • (Results not yet available from the abstract)

Conclusions:

  • Findings will inform a Theory of Change on developmental origins in diverse Indian settings.
  • Results can guide interventions for child development beyond the first 1000 days, applicable to under-resourced global contexts.
Abstract

Keywords:
air pollutionchild mental healthcognitive developmentearly-life stressglobal Southnurturing care frameworknutritionpesticide

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