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Published on: March 15, 2022
Antiplatelet Agents in Endovascular Neurointerventional Procedures.
Kelley Flesher1, Sophia Pathan1,2, William Andrew Kofke1
1Department of Neurology, Neurocritical Care Division, University of Pennsylvania, Philadelphia, PA.
Periprocedural antiplatelet agents improve outcomes in neurointerventional procedures. Standardized regimens and monitoring are needed to optimize safety and efficacy for patients undergoing these minimally invasive treatments.
Area of Science:
- Neurology
- Cardiology
- Interventional Radiology
Background:
- Minimally invasive, image-guided endovascular procedures, especially neurointerventions, are increasingly common.
- These procedures carry a risk of endothelial injury, leading to thromboembolic complications.
- Managing antiplatelet therapy is crucial due to the dual risk of thromboembolic and hemorrhagic complications.
Purpose of the Study:
- To review the mechanisms of action, clinical indications, and management of antiplatelet agents in neurointerventional procedures.
- To highlight the current variability in clinical practice and the need for standardization.
Main Methods:
- Focused review of existing literature and clinical consensus on antiplatelet therapy in neurointerventions.
- Discussion of antiplatelet agent mechanisms and their application in periprocedural settings.
Main Results:
- Clinical consensus supports the use of periprocedural antiplatelet agents for improved patient outcomes.
- Current practices for antiplatelet use are highly variable across institutions and practitioners.
Conclusions:
- Antiplatelet agents are vital in managing patients undergoing endovascular neurointerventions.
- Further research is required to establish standardized, procedure-specific antiplatelet regimens and monitoring protocols.
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