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Visualization of DNA Replication in the Vertebrate Model System DT40 using the DNA Fiber Technique
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Dual DNA replication modes: varying fork speeds and initiation rates within the spatial replication program in

Diletta Ciardo1, Olivier Haccard2, Francesco de Carli1

  • 1Institut de Biologie de l'Ecole Normale Supérieure, Ecole Normale Supérieure, CNRS, INSERM, Université PSL, F-75005 Paris, France.

Nucleic Acids Research
|January 30, 2025
PubMed
Summary

Researchers discovered two DNA replication modes in Xenopus, a fast and slow process. Polo-like kinase 1 (Plk1) is crucial for coordinating these modes during S phase.

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