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Molecular and therapeutic insight into ER stress signalling in NSCLC.

Aastha Jadhav1, Arjun Menon1, Kush Gupta1

  • 1Department of Biotechnology and Bioengineering, Institute of Advanced Research, Gandhinagar, Gujarat, India.

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Summary

Endoplasmic Reticulum (ER) stress impacts lung cancer development and chemotherapy response. Targeting ER stress pathways offers new therapeutic strategies to improve patient survival in Non-Small Cell Lung Cancer (NSCLC).

Keywords:
ATF6ER stressIRE1PERKchemoresistancemiRNAnon-small cell lung cancer (NSCLC)

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Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Endoplasmic Reticulum (ER) stress is implicated in cancer development, progression, and chemotherapy resistance.
  • ER stress-related genes may serve as prognostic markers in lung adenocarcinoma.

Purpose of the Study:

  • To review the role of major ER stress pathways (IRE1, ATF6, PERK) in Non-Small Cell Lung Cancer (NSCLC) pathogenesis.
  • To explore the influence of ER stress on the tumor microenvironment, metastasis, angiogenesis, apoptosis, and N-glycosylation.
  • To discuss microRNA regulation of ER stress and therapeutic strategies against chemoresistance.

Main Methods:

  • Literature review of ER stress pathways in NSCLC.
  • Analysis of ER stress modulation of tumor microenvironment and related processes.
  • Discussion of microRNA roles and therapeutic targeting of ER stress.

Main Results:

  • ER stress pathways significantly influence NSCLC pathogenesis via tumor microenvironment modulation.
  • ER stress affects key cancer processes including metastasis, angiogenesis, apoptosis, and N-glycosylation.
  • MicroRNAs play a regulatory role in ER stress pathways within NSCLC.

Conclusions:

  • Targeting ER stress pathways presents promising therapeutic opportunities to overcome chemoresistance in NSCLC.
  • Understanding ER stress mechanisms can lead to improved treatment outcomes and survival rates for lung adenocarcinoma patients.