Nanozymes meet hydrogels: Fabrication, progressive applications, and perspectives

Nanozyme, a class of emerging enzyme mimics, is the nanomaterials with enzyme-mimicking activity, which has obtained significant and widespread applications in various fields. However, they still face many challenges in practical applications (e.g., instability and low biocompatibility in the physiological environments), which affect their widespread applications to a certain extent. Hydrogels with superior performances (e.g., the controllable degradability, good biocompatibility, hydrophilic properties, and adjustable physical properties) may provide a promising strategy to make up the existing deficiencies of nanozymes in practical applications. Thus, the sapiential combination of nanozymes with hydrogels endows nanozyme hydrogels with both characteristics of nanozymes and properties of hydrogels, making nanozyme hydrogels become novel multifunctional materials. In this review, we comprehensively summarizes the preparation, properties, and progressive applications of nanozyme hydrogels. First of all, the main design and preparation strategies of nanozyme hydrogels are considerately summarized. Then, the properties of different nanozyme hydrogels are introduced. In addition, sophisticated applications of nanozyme hydrogels in the fields of biosensing, biomedicine applications, and environmental are comprehensively summarized. Most importantly, future obstacles and chances in this emerging field are profoundly proposed. This review will provide a new horizon for the development and future applications of novel nanozyme hydrogels.