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Synthesis and characterization of thermally stable and water-soluble pantetheine trisulfide and its composites

Shoichiro Tomonaga1,2, Hiroaki Ishimaru1, Shizuki Misada1

  • 1Kyowa Pharma Chemical Co., Ltd, Toyama, Japan.

Bioscience, Biotechnology, and Biochemistry
|January 31, 2025
PubMed

Keywords:
heat stabilitypantetheine trisulfidepharmaceutical compositesupersulfidewater solubility

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Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
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