Related Experiment Video

Updated: May 12, 2026

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
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Role of miRNA‑145‑5p in cancer (Review)

Zeshan Chen1, Yijue Qin1

  • 1Department of Traditional Chinese Medicine, Guangxi Zhuang Autonomous Region People's Hospital, Nanning, Guangxi 530016, P.R. China.

Oncology Reports
|January 31, 2025
PubMed

Insights

MicroRNA-145-5p plays a dual role in cancer, acting as a tumor suppressor or oncogene. This review explores its potential as a diagnostic and prognostic biomarker and its impact on cancer therapy.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNA-145-5p (miRNA-145-5p) is a non-coding RNA involved in cellular regulation.
  • Its function in malignant tumors can be either tumor suppressive or oncogenic, influencing cancer progression.
  • The complete role of miRNA-145-5p in cancer requires further elucidation.

Purpose of the Study:

  • To provide a comprehensive overview of miRNA-145-5p's role in cancer.
  • To investigate its potential as a biomarker for cancer diagnosis, prognosis, and treatment response.
  • To evaluate its influence on chemotherapy and radiotherapy efficacy.

Main Methods:

  • Literature review and synthesis of existing research on miRNA-145-5p in cancer.
  • Analysis of studies investigating miRNA-145-5p's targets and regulatory mechanisms.
  • Summary of current findings on miRNA-145-5p's clinical applications and delivery strategies.

Main Results:

  • miRNA-145-5p exhibits context-dependent roles in various cancers, acting as both a tumor suppressor and an oncogene.
  • It influences tumor progression by targeting downstream genes and interacting with upstream regulators.
  • Emerging evidence suggests its potential as a biomarker for early detection and predicting treatment outcomes.

Conclusions:

  • miRNA-145-5p is a significant factor in cancer development and progression.
  • Its multifaceted roles highlight its potential as a versatile biomarker and therapeutic target.
  • Further research into its delivery mechanisms is crucial for effective cancer therapy.
Keywords:
biomarkerscancerchemotherapydelivery systemsdiagnosticsmiRNA‑145‑5pprognosticsvector

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