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Updated: May 11, 2026

Genome-wide Screen for miRNA Targets Using the MISSION Target ID Library
Published on: April 6, 2012
Role of miRNA‑214‑3p in cancer (Review)
Zeshan Chen1, Xin Deng2, Yuanhong Lu3
1Department of Traditional Chinese Medicine, Guangxi Zhuang Autonomous Region People's Hospital, Nanning, Guangxi 530016, P.R. China.
Abstract:
microRNA‑214‑3p (miRNA‑214‑3p) can be mapped to the human chromosome 1q24.3 and is ~22 nucleotides in length. It has been garnering considerable attention due to its aberrant expression profile in various different types of cancer and its apparent role in regulating tumor progression. In malignant tumors, miRNA‑214‑3p can serve as a tumor suppressor or oncogene. This can be mediated by mainly inhibiting the expression of target genes by binding to the 3'‑untranslated region of target mRNAs, thereby regulating multiple downstream cellular processes, such as cell proliferation, metastasis, invasion and apoptosis. However, the role of miRNA‑214‑3p in cancer remains unclear. Therefore, in the present review, the role of miRNA‑214‑3p in cancer was summarized, whilst analyzing its potential as a biomarker for cancer diagnosis, prognosis and response to treatment. In addition, the present review evaluates its effects on sensitivity to chemotherapy, targeted therapy and radiotherapy. The current proposed strategies for the systemic delivery of miRNA‑214‑3p in cancer were also discussed.
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