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Vineland-3 Growth Scale Values: Psychometric Properties for Clinical Trial Readiness in SCN2A
Aaron J Kaat1, Lindsey Evans2, Amanda N Nili1
1Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Journal of Child and Adolescent Psychopharmacology
|January 31, 2025
Summary
The Vineland Adaptive Behavior Scales-3rd Edition (Vineland-3) shows strong psychometric properties for assessing adaptive behavior in sodium channel protein type 2 subunit alpha related disorders (SCN2A-RDs). Its growth scale values (GSVs) are promising for clinical trials in SCN2A-RDs.
Area of Science:
- Neuroscience
- Clinical Psychology
- Developmental Pediatrics
Background:
- Sodium channel protein type 2 subunit alpha related disorders (SCN2A-RDs) are increasingly recognized, necessitating reliable outcome measures.
- Disease-modifying treatments for SCN2A-RDs are in early development, highlighting the need for robust clinical outcome assessments (COAs).
- The Vineland-3, a widely used adaptive behavior measure, introduced growth scale values (GSVs) for tracking within-individual changes.
Purpose of the Study:
- To evaluate the psychometric properties of Vineland-3 growth scale values (GSVs) in individuals with SCN2A-RDs.
- To determine the suitability of Vineland-3 GSVs as a clinical outcome assessment for future SCN2A-RD clinical trials.
Main Methods:
- A cohort of 65 individuals with SCN2A-RDs was assessed using the Vineland-3 Comprehensive Interview.
- Psychometric properties examined included floor/ceiling effects, internal consistency (split-half reliability), test-retest reliability, and inter-rater reliability.
- Reliability analyses were conducted on all subdomains, with inter-rater reliability assessed on a subset of interviews.
Main Results:
- Floor effects were infrequent for Vineland-3 GSVs but present for norm-referenced v-scales in some subdomains.
- Excellent split-half and test-retest reliability (rxx >0.95, ICC >0.90) were observed across most subdomains.
- Adequate reliability was found for the coping subdomain (rxx = 0.87, ICC = 0.65), and strong inter-rater reliability (Kripp's alpha range 0.78-1.00) was noted.
Conclusions:
- The Vineland-3 demonstrates strong psychometric performance in individuals with SCN2A-RDs, supporting its use as a COA.
- Vineland-3 GSVs are a viable metric for measuring change in SCN2A-RD clinical trials.
- Further research, including mixed-methods approaches, is recommended to refine the relevance of specific Vineland-3 domains for this population.
