Related Experiment Video
Updated: May 30, 2025
09:12
A Pre-Clinical Porcine Model of Orthotopic Heart Transplantation
Published on: April 27, 2019
9.5K
SherpaPak Cardiac Transport System: Experience in Pediatric Heart Transplantation
Anna Sather1, Molly Marshall2, Raghav Murthy3
1Department of Environmental Medicine and Climate Science, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Clinical Transplantation
|January 31, 2025
Summary
The SherpaPak Cardiac Transport System demonstrates safe clinical outcomes in pediatric heart transplantation, even for complex congenital heart disease cases. No mortality was observed in this study group.
Area of Science:
- Cardiology
- Pediatric Surgery
- Transplantation Medicine
Background:
- Assessing clinical outcomes of pediatric heart transplant recipients.
- Evaluating the efficacy of the SherpaPak Cardiac Transport System for donor heart preservation.
- Focusing on pediatric patients undergoing heart transplantation.
Purpose of the Study:
- To evaluate the clinical outcomes of pediatric heart transplant patients using the SherpaPak Cardiac Transport System.
- To compare outcomes between pediatric heart transplant recipients with cardiomyopathy versus congenital heart disease (CHD).
Main Methods:
- Retrospective analysis of 18 pediatric heart transplant patients (Jan 2020 - June 2024).
- Comparison of outcomes between cardiomyopathy and CHD groups.
- Statistical analysis using chi-square, Fisher exact, Mann-Whitney U, and t-tests.
Main Results:
- No significant differences in Vasoactive Inotropic Score (VIS) or primary graft dysfunction (PGD) between groups.
- Congenital heart disease (CHD) group had longer circulatory arrest and bypass times (p < 0.05).
- Three patients (all with CHD) experienced early rejection; no mortality observed.
Conclusions:
- The SherpaPak Cardiac Transport System is safe for pediatric heart transplantation, including complex CHD cases.
- Further multi-institutional and registry studies are warranted to validate these findings.
- The system supports successful pediatric heart transplantation outcomes.
