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Updated: May 30, 2025

Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples

Four-color Fluorescence Immunohistochemistry of T-cell Subpopulations in Archival Formalin-fixed, Paraffin-embedded Human Oropharyngeal Squamous Cell Carcinoma Samples

Published on: July 29, 2017

Assessing the Correlation Between Langerhans Cells Population and Prognosis of Tongue Squamous Cell Carcinoma.

Narges Ghazi¹, Nasrollah Saghravanian¹, Pooya Saeedi²

¹Department of Oral and Maxillofacial Pathology, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.

Clinical and Experimental Dental Research

|January 31, 2025

Summary

A lower count of Langerhans cells (LCs), identified by CD1a expression, is linked to poorer outcomes in tongue squamous cell carcinoma (TSCC). This suggests LCs may be a key prognostic factor for TSCC patients.

Keywords:

CD1a Langerhans cell prognosis tongue squamous cell carcinoma

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Area of Science:

Oncology
Immunology
Pathology

Background:

Tongue squamous cell carcinoma (TSCC) is a prevalent oral cancer with stagnant survival rates.
Langerhans cells (LCs) are crucial for antitumor immunity.
The prognostic value of LC counts in TSCC requires further investigation.

Purpose of the Study:

To evaluate the correlation between Langerhans cell (LC) density and disease prognosis in tongue squamous cell carcinoma (TSCC).
To determine if CD1a immune expression can serve as a prognostic biomarker for TSCC patients.

Main Methods:

Histopathologic analysis of 24 TSCC cases and 12 normal tissue controls.
Immunohistochemical staining using the CD1a marker to quantify LC density.
Statistical analysis to assess the impact of CD1a+ cell counts on patient survival and clinicopathological variables.

Main Results:

A significant decrease in CD1a+ cell counts was observed in advanced-stage TSCC compared to early-stage and normal tissues.
Lower CD1a+ cell counts correlated significantly with poorer disease-free survival (DFS) and overall survival (OS).
CD1a+ cell count was an independent predictor of DFS (p=0.002) but not OS (p=0.210).

Conclusions:

CD1a+ cell count is significantly correlated with patient prognosis and survival rates in TSCC.
LCs, as indicated by CD1a expression, represent a potential prognostic factor for managing TSCC.
Further research into LC-based biomarkers could improve TSCC patient management.