NeOPT: neural optical projection tomography with low-cost imaging setup

Optical projection tomography (OPT) is an imaging technology that employs light to reconstruct 3D models of objects. Recent advancements in neural radiance field (NeRF) have improved 3D biomedical imaging, yet they perform suboptimally with low signal-to-noise ratio (SNR) data in low-cost setups and are not directly applicable to OPT systems. Here, we introduce neural optical projection tomography (NeOPT), leveraging a low-cost OPT imaging setup combined with a pose-robust neural-based 3D reconstruction method to achieve high-quality OPT results. NeOPT incorporates discrete wavelet transform (DWT) to reduce imaging noise under low-SNR conditions. Experiments demonstrate that NeOPT significantly outperforms traditional OPT techniques.