Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Peritoneal Tuberculosis Complicated by Abdominal Abscesses: Diagnostic Challenges and Clinical Insights From Two Cases.

Journal of investigative medicine high impact case reports·2026

Same author

Peritoneal melanosis: case report and literature review.

Journal of surgical case reports·2026

Same author

Bridging Theory and Practice: Patho-Play as an Innovative Serious Game for Pathology Training in Medical Education.

La Tunisie medicale·2026

Same author

Rare internal malignancies in xeroderma pigmentosum: A report of two cases from Tunisia and analysis of driver mutations.

Cancer pathogenesis and therapy·2026

Same author

Clinical symptoms and radiological sequels after SARS-CoV-2 pneumonia: A longitudinal study.

La Tunisie medicale·2026

Same author

The role of CDX2 immunohistochemical marker in colorectal adenocarcinoma « CDX2 in colorectal adenocarcinoma ».

La Tunisie medicale·2026

Search research articles

Related Experiment Video

Updated: May 30, 2025

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

Primary retroperitoneal synovial sarcoma (RSS): A case report.

Sarra Ben Rejeb¹, Safia Sakly¹, Majdi Ben Romdhane²

¹Pathology Department, Security Forces Hospital, Marsa, Tunisia.

International Journal of Surgery Case Reports

|January 31, 2025

Summary

Retroperitoneal synovial sarcoma (RSS) is rare and often misdiagnosed as leiomyosarcoma. Accurate diagnosis requires immunohistochemistry and molecular testing to improve patient outcomes for this challenging soft tissue sarcoma.

Keywords:

Retroperitoneal Synovialsarcoma Tumor

More Related Videos

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies

Published on: July 28, 2020

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

Related Experiment Videos

Last Updated: May 30, 2025

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Establishment of a Primary Culture of Patient-derived Soft Tissue Sarcoma

Published on: April 11, 2018

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies

Published on: July 28, 2020

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate

Published on: May 3, 2021

Area of Science:

Oncology
Pathology
Genetics

Background:

Retroperitoneal soft tissue sarcomas are predominantly leiomyosarcoma and liposarcoma.
Synovial sarcoma (SS) is an exceptionally rare retroperitoneal tumor, with fewer than 30 reported cases.
Misdiagnosis of SS is common due to its rarity and overlapping histological features with other sarcomas.

Observation:

A 38-year-old woman presented with a large, heterogeneous retroperitoneal mass.
Initial biopsy was inconclusive; histopathology suggested leiomyosarcoma.
Recurrent tumor showed increased cellularity and mitotic activity, prompting further investigation.

Findings:

Immunohistochemistry revealed BCL2, EMA, and TLE1 positivity, raising suspicion for SS.
Molecular analysis confirmed the SS18-SSX translocation, diagnosing high-grade monophasic synovial sarcoma.
The patient experienced rapid recurrence and mortality within six months despite treatment.

Implications:

Retroperitoneal synovial sarcoma (RSS) presents significant diagnostic challenges, necessitating consideration in the differential diagnosis of spindle cell tumors.
Immunohistochemical panels (TLE1, BCL2, EMA) and molecular confirmation (SS18-SSX fusion) are crucial for accurate diagnosis.
Early and accurate diagnosis of RSS is vital to avoid delayed management and improve patient outcomes.