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Updated: May 30, 2025

Monitoring PD-1-Blocking Antibodies Bound to T Cells Derived from a Drop of Peripheral Blood
Published on: February 5, 2020
Circulating T cells fuel anti-PD-1 and lenvatinib efficacy
Peter J Matulich1, Megan L Burger2
1Department of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, OR, USA.
Abstract:
The mechanisms underlying synergy between checkpoint blockade and anti-angiogenic therapy remain elusive. In this issue of Cancer Cell, Guo et al. analyze hepatocellular carcinoma patients treated with anti-PD-1 and lenvatinib, identifying a circulating CD8+ T cell population critical for treatment efficacy. Engaging these cells could enhance immunotherapy across other settings.
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