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Updated: May 29, 2025

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
Published on: November 21, 2013
Self-Assembly of Quinazolinedione Rosettes
Yuhei Yamada1, Hiroki Hanayama2, Takashi Kajitani3
1Division of Advanced Science and Engineering, Graduate School of Science and Engineering, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba, 263-8522, Japan.
Abstract:
A quinazoline-2,4(1H,3H)-dione bearing a phenylene moiety and aliphatic tails was synthesized as an alternative self-assembling building block to barbiturate molecules, aiming to achieve enhanced hydrolysis resistance. The compound self-assembles in non-polar solvents to form linear supramolecular polymers via the formation of hydrogen-bonded cyclic hexamers (rosettes), a process confirmed by powder X-ray diffraction (PXRD) analysis of the bulk material. Our results demonstrate that quinazoline-2,4(1H,3H)-dione serves as an effective hydrogen-bonding building block, suggesting its potential to form stable supramolecular polymers from versatile π-conjugated molecules.
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