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Associations of chronic kidney disease with hidradenitis suppurativa: A bidirectional Mendelian randomization study

Yang Xu1, Yiling Yang1, Weisheng Zhan2

  • 1Department of Dermatology, Nanchong Central Hospital, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, Sichuan, China.

The Journal of Dermatology
|February 1, 2025
PubMed

Insights

Chronic kidney disease (CKD) significantly increases the risk of developing hidradenitis suppurativa (HS). This study found no evidence that HS causes CKD, suggesting a one-way causal link from kidney disease to skin condition.

Area of Science:

  • Nephrology
  • Dermatology
  • Genetics

Background:

  • Observational studies suggest a link between chronic kidney disease (CKD) and hidradenitis suppurativa (HS).
  • The causal relationship between CKD and HS remains undetermined.

Purpose of the Study:

  • To investigate the causal direction between CKD and HS using bidirectional Mendelian randomization (MR).

Main Methods:

  • Bidirectional MR analysis utilizing summary statistics from genome-wide association studies.
  • Inverse variance weighting (IVW) as the primary method, with sensitivity analyses for robustness.

Main Results:

  • CKD was significantly associated with an increased risk of HS (OR=1.577, P=0.023).
  • Estimated glomerular filtration rate (eGFR) did not show an increased risk for HS.
  • Reverse MR analysis indicated no significant causal effect of HS on CKD.

Conclusions:

  • This study provides robust evidence that CKD is a significant risk factor for developing HS.
  • The findings suggest a unidirectional causal relationship where CKD predisposes individuals to HS.

Keywords:
Mendelian randomizationchronic kidney diseaseeGFRgenome‐wide association studyhidradenitis suppurativa

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